YK-11

Volume: 30 ML

Dosage: 10 MG/ML

Clinical dosing: 2.5 - 15 mg/day

Description:

YK-11 is a synthetic steroidal selective androgen receptor modulator (steroidal SARM). It is a steroid compound based on 5-α-dihydrotestosterone (DHT), which is a gene-selective and partial agonist of the androgen receptor (AR). YK11 is so far the only SARM that is able to increase the expression of the activin binding protein Follistatin (FST), and right the induction of FST plays a key role in its anabolic effects. YK11 has chemical formula C25H34O6 and molecular mass 430.541 g·mol−1. YK11 has a similar chemical structure to the dihydrotestosterone (DHT) from which it is derived, and both hormones YK11 and DHT bind to androgen receptors (AR). However, unlike DHT, YK11 does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR. In other words said, YK11 activates AR only partially, without the N/C interaction. Such partial (limited) activation of androgen receptors increases the catabolic activity in the body. However, YK11 also induces the expression of Follistatin (FST), an autocrine glycoprotein that is a potent inhibitor of the effects of Myostatin, a protein that brakes muscle growth. Thus, the resulting potent anabolic effect of YK11 is thought to be primarily due to the induction of expression of Follistatin, which blocks effects of Myostatin. The resulting anabolic activity of YK11 in C2C12 myoblasts is more potent than the anabolic activity of DHT.

Compound Specifications:

Originale product made in UK.